The family of a doctor, who will be doing surgery on the United States President, is taken hostage by a rogue FBI agent. She is ordered by the kidnappers to assassinate the President in order to save her family.
Ellen has to make another life-changing choice when she performs emergency surgery in her own home. Meanwhile, Duncan demands answers when Archer tells him that an innocent person in their plan has become a victim.
When Ellen's sister, Lauren, shows up unexpectedly at their house intending to stay, Duncan forces Ellen to get rid of her without making it look suspicious. Meanwhile, the secret service calls Ellen in for questioning again and she must play it cool when Duncan is there to help do the questioning.
Ellen and Brian agree that they need to take down Duncan to have any chance of escaping, so she sneaks away to see a man who has previously helped her solve problems. However, unbeknownst to her, this man has ties to Duncan. Meanwhile, Archer's accomplice plans to reveal to the Assistant District Attorney information about a murder Archer committed.
Ellen must decide whether to save Duncan's life, and later decides to confront his wife. Meanwhile, Creasy meets with Vanessa and Colonel Blair after the President informs them that he wants to expose the details of Operation Total Information, a government surveillance program that allowed intelligence agencies to spy on U.S. citizens.
When investigators get closer to discovering the conspiracy to kill the President, Duncan is ordered to get rid of an insider by someone very connected to the plot. Meanwhile, Duncan takes the next step in his master plan and gives Ellen the poison she is to use to kill the President.
After a member of the President's staff is murdered, Ellen urges Duncan to back out of the assassination plot, while other members of the President's staff take matters into their own hands. Meanwhile, after scouring medical records, Ellen finds someone who might be a viable bone marrow donor for Duncan's wife, Nina.
Duncan locks the Sanders family in a room for the day while he and his team head to New York City to eliminate the sniper team targeting President Kincaid. Meanwhile, Duncan's mother-in-law, Kate, tells Burton she wants to expose the President.
When Brian goes to the police to expose Duncan and his team, he decides against telling the truth after Burton shows up and shows him evidence of Ellen and Duncan getting close. Meanwhile, Duncan's trip to New York City puts a snag in the plans to take out the President.
Ellen reveals to Duncan that she will not kill the President but will help him get what he needs, as long as he gives her something in return. Meanwhile, Nina finds out about Duncan's plan and flees the hospital.