London 1891. As the police investigate a series of gruesome murders, renowned explorer Sir Malcolm Murray and the strangely beautiful Vanessa Ives know there's something darker at play. In search of someone close to them who has been lost, they recruit American sharp-shooter Ethan Chandler and Dr. Victor Frankenstein to help them on their journey.
Vanessa and Sir Malcolm attend the party at Ferdinand Lyle's home in the hopes of learning more about the the Egyptian hieroglyphs found on the dead creature. Vanessa meets the ever young Dorian Gray. Vanessa also participates in a séance where she proves to the spirit world's conduit. Meanwhile, Ethan Chandler makes the acquaintance of a prostitute, Bona Croft. She in turn has a session with young Gray. Elsewhere, Victor Frankenstein is amazed at how quickly his creation, who he has named Proteus, can learn. It all comes to a surprising end however.
A flashback reveals Victor Frankenstein's motivation for delving into the questions of life and death. Flashbacks also show the history of Victor's "first-born". The Creature was born in a state of unending agony and Victor fled, rejecting his creation. It eventually came into contact with actor Vincent Brand who gives him a job working with the stage equipment and rigging at a theater. He has a very particular request for his maker - a female companion. After her experience at the séance, Vanessa continues to have a spiritual link with Mina who is desperate to be ...
Frankenstein consults a hematologist, Professor Abraham Van Helsing, who finds the blood contains an unique property that prevents complete coagulation. He believes it assists in the eating of blood. Frankenstein begins experimenting on Fenton, the vampire they caught and are keeping in chains. Frankenstein is also having to deal with his creature who wants him to create a female companion for him. Chandler takes Brona to the Grand Guignol theater. Gray is there, as is Vanessa, but it's Chandler he is interested in.
Sir Malcolm, Ethan and Sembene follow their vampire lead to a quarantined ship to find Mina only to see her taken away again. Vanessa has a violent sexual escapade with Dorian, where she is met with the voice again and storms out. Van Helsing tells Victor about the true nature of the creatures they are hunting but is murdered by Caliban, who intends to start killing everyone close to his creator. Brona apologizes to Ethan for her behavior previously.
Vanessa starts having "unnatural" fits and mentions that she is trying to fight the "thing inside me". Malcolm tells Ethan that she might be possessed by "the devil" or "a devil" and wants to keep her alive. Vanessa talks to the entity possessing her which reveals that it wants her to be "the mother of evil". Victor asks Ethan to teach him how to shoot. A glimpse at Sambene's past and Malcolm's true intentions is shown.