Adrian Hough, who plays Victor Rogers in this episode, also played Dr. Hydecker in season 1 episode 18, Something Wicked (2006).
Madison McLaughlin first played her character Krissy Chambers in Season 7 Episode 11, Adventures in Babysitting (2012).
When Sam suggests that Krissy's dad doesn't know what she's doing, Dean says, "What, sneaking out in the middle of the night to hunt monsters with the Apple Dumpling Gang?" He is referring to the Disney comedy, The Apple Dumpling Gang (1975), starring Don Knotts and Tim Conway.
Dean catches up with Krissy as she takes down the vampire and asks the whereabouts of the blue van "that he was Usain Bolting it to." Dean is referring to the Jamaican sprinter who is the first man to win six gold medals in sprinting in the modern Olympic Games.