When the guys save a landlord with a nut allergy, Johnny finds the perfect apartment to share with Theresa, and his relationship with her enters a new territory. Meanwhile, Brian tries to understand the terms of his platonic love affair with Voodoo, Billy starts dating Theresa's sister, and Hank has to wonder if he's looking for love in the right places.
The guys explore ideas of fate and serendipity after several random but fortuitous events, and Johnny gets bent out of shape when he discovers that Theresa doesn't think it was "destiny" that they met.
Johnny has to deal with his prejudice against "rich white guys" when Hank starts dating Johnny's wealthy landlord. Meanwhile, Billy helps Brian work through his heartbreak after Voodoo starts seeing a guy she met on an asexual message board.
After they save a local mobster (the Soprano's Steve Schirripa), Brian tries to get the guys to makes some changes in the rig, Hank considers the worst person he's ever helped, and Billy goes looking for his old neighborhood pony.
When Johnny's dad goes into a coma, Johnny's mom deals with her grief by placing bets on the time of her ex-husband's death and Johnny handles his own grief by trying to pay off an old debt. Meanwhile the guys can't get an unfortunate song out of their heads.