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The song that Mama Imelda and Ernesto de la Cruz sang towards the end of the film is called "La Llorona", a classic and anonymous Mexican song. One popular interpretation of the song is about a singer feeling trapped by this woman (La Llorona) who has fallen in love with him. Another interpretation is a woman's grief about drowning her children in a river. This version is an urban legend in Mexico.
Miguel was originally only going to play guitar and not sing. When the director, Lee Unkrich, discovered Anthony Gonzalez was, in fact, a talented singer, it was decided Miguel would do both so Anthony could share this talent in the film.
Spent more days #1 at the box office than any other animated film in the 21st century.
The orange flower seen throughout the film is the Aztec marigold (known also as the Mexican marigold or the Cempasúchil). The flower is used in the tradition of Dia de los Muertos in México to guide the deceased to the living.
The film contains specific themes and content which would ordinarily be banned in China. Reportedly, the Chinese censor board members were so touched by the film that they made an exception and allowed it.
John Ratzenberger, long considered Pixar's good-luck charm, continues his streak of appearing in all of the studio's feature films. In Coco (2017), he plays a ghost called Juan Ortodoncia. He is the skeleton who can cross over to the land of the living because his dentist remembers him.