In late nineteenth-century America, a frontier holy man's life is destroyed as a gruesome power consumes the land. Standing between ruin and salvation, the man known only as Preacher must find his purpose in the fight against the mysterious undead. Joined by the town Marshal a man with his own set of demons he faces the risen dead, a ravaged landscape and the evils of the living on a journey to nowhere. Along the way, the men learn which lines they're willing to cross to make it to the next day, as well as the depths people reach through the power of belief - for good and ill alike.