Director Phil Coulson and Agent Daisy Johnson leading the charge as S.H.I.E.L.D. searches the world for more powered people in the aftermath of their epic battle with Jiaying and her army of Inhumans. However, Coulson and the team soon find out that they are not the only group looking for these new Inhumans.
Having reluctantly agreed to share information with Rosalind and the ATCU, Coulson and the team search for the Inhuman who is killing other Inhumans; May feels that Hunter's mission to take down Ward is getting too personal.
As Daisy and the team try to protect Inhumans, a shocking truth is revealed about S.H.I.E.L.D.'s biggest enemy; with Fitz's help, Simmons recovers information that could get them back through the portal.
Coulson is more determined than ever to get to Gideon Malick and put to an end to Hydra once and for all in the aftermath of his trip to Maveth. Meanwhile, Daisy and the team encounter more Inhumans who have powers like they've never seen before, but will they be friends or enemies of S.H.I.E.L.D?
Agent Daisy Johnson must call upon the Secret Warriors for an inaugural mission that will leave no member unscathed, and S.H.I.E.L.D. learns more about Hive's powers, forcing them to question everyone they trust.
The S.H.I.E.L.D. team is left reeling and decimated as Hive continues to sway Inhumans to his side. But there is a sliver of hope as Agents Fitz and Simmons follow a lead that may be able to stop the maniacal Inhuman once and for all.
In the aftermath of the events of Captain America: Civil War (2016), S.H.I.E.L.D feels pressure to reveal their involvement with Inhumans. But with the stakes higher than ever and Hive growing stronger, the team is tested in ways they could never anticipate.