This is the fourth collaboration between Julia Roberts and George Clooney--they previously co-starred in Oceans Eleven, Ocean's Twelve and Confessions of a Dangerous Mind. Clooney produced August: Osage County in which Roberts starred.
The trivia item below may give away important plot points.
Jodie Foster was considered for Julia Roberts's roles in Pretty Woman as Vivian Ward the prostitute and Conspiracy Theory as Alice Sutton from the justice department who is good friends with Mel Gibson's character ironically even real life. Conspiracy Theory would have reunited her with Gibson and Richard Donner who she worked with on Maverick in 1994.