After Jody tries to win Mindy's heart by buying her an apartment, Mindy is torn between her old love, Danny, and a relationship with Jody. Tamra is suspicious about Mindy's trip to Miami so she and Colette go undercover to figure out what really happened.
While Mindy struggles to take care of a sick Leo, Shulman and Associates is rocked by a nurses' strike led by Ben, a handsome male nurse. Meanwhile, Jody tries to sell the upstairs apartment and Brendan Deslaurier comes to Mindy seeking help.
The nurses' strike continues, while Mindy finds herself having romantic feelings for the enemy - Ben, the leader of the nurses. As the doctors and nurses try to stay strong, Jeremy finds that the stress is taking a serious toll on his health.
As Jeremy recovers from his heart attack, the practice needs another doctor. Jeremy and Jody want to hire a woman, but Mindy isn't sure about sharing the spotlight. Meanwhile, she and Ben are getting serious.
When Mindy discovers that her new boyfriend isn't being exclusive, she goes on a date with a famous actor aka "the bad boy of London theater." The nurses try to cheer up Jody, who's lost his mojo, and discover he might be planning something drastic.
Mindy escapes to her childhood home in Massachusetts and discovers that her mom is using dubious methods to further her acting career in local theater. As Mindy and Rishi try to intervene, she learns that Danny is having doubts about marrying Sarah.
A heartbroken Anna grieves her breakup at Mindy's place, while Jody and Jeremy compete for her affection. Morgan, trying to jump-start his dating life, blows up at Colette's new girlfriend, Karen, when she accidentally interrupts his make out session.
Mindy is unfairly passed over for a promotion and goes to bed wishing things were different. She wakes up in the body of a handsome white man and quickly discovers the perks that come with white male privilege.
Mindy's world is turned upside down when her cool friend from childhood moves to New York and starts dating Morgan. Meanwhile Ben has to cover his tracks after the nurses spot him in a provocative situation.