The game takes place in Sanctuary, the dark fantasy world of the Diablo series, twenty years after the events of Diablo II. Deckard Cain and his niece Leah are in Tristram Cathedral investigating ancient texts regarding an ominous prophecy. A mysterious star falling from the sky strikes the Cathedral, creating a deep crater into which Deckard Cain disappears. Written by
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[Leah helps lay her uncle, Deckard Cain, to rest outside Tristram; she places a book on his chest
It was all just stories... my uncle saw what he wanted to see.
Deckard sacrificed much to protect this world, but his work is not over.
What would YOU know about sacrifice?
[In reply, Tyrael grasps her arm gently - showing her a vision of himself as an angel, before the Angiris Council
Tyrael, the ancient law of the High Heavens strictly forbids us from interfering from the mortal world... yet YOU ...