The Night Shift Belongs to the Stars is the story of Matteo (Enrico Lo Verso), and Sonia (Nastassja Kinski). Their friendship starts in a hospital on the eve of their respective open heart surgeries. Matteo receives the gift of a new life through a heart transplant while Sonia undergoes an open heart operation to put in a new mitral valve. The path to recovery will be connected to the passion they both share for mountaineering and the promise to climb together a peak on the Dolomites, in Trentino, Italy. Will their hearts survive the challenge? While Sonias husband, Mark (Julian Sands), worries about his wife and feels threatened by the complicity between Sonia and Matteo, the two aim for the summit, opening the route to a new beginning and a second chance at life.