After years building their alligator rescue program, the Gator Boys must leave Everglades Holiday Park. Jimmy finds a gator ranch in Mississippi, but Paul is reluctant to move and work for someone else. Paul must decide if they will move or close forever.
Between a flat tire and getting lost, Paul and Jimmy are off to a rocky start in Mississippi. Catching gators in murky swamps puts the Gator Boys in great peril. They must finish a gator pit in the sweltering heat before wrestling shows can begin.
The Gator Boys continue to capture dangerous nuisance alligators. After they learn about a legendary swamp creature lurking deep in the Bayous of Mississippi, Tre gets sidetracked on a mission to find the half-man, half-gator.
The Gator Boys search for Big Bull, a legendary 15-foot alligator. After many false leads, they find the mythical beast and realize it is way too big for just the two of them to handle. Paul and Chris battle to know what is better: whips or knives.
The Gator Boys need help after being slammed with a series of huge nuisance gators. A young boy jumps in a pool with a gator, and Paul must avert disaster. Ashley recruits Scott to help with a PR scheme, until it involves him dressing in a gator costume.
Wild Mississippi gators begin fighting with Paul's Florida gators. Allan and Curtis insist Mississippi gators are a better, stronger species. Paul calls in an expert to prove them wrong. Jimmy's busy schedule leaves Sara feeling neglected.
Paul is in Florida dealing with an emergency while Jimmy rallies the Gator Boys to handle multiple nuisance calls along the Mississippi Gulf Coast. When Tre is attacked by a giant gator, Scott struggles to get him out of the swamp before it's too late.