- This is John Goodman's fourth live-action adaptation of a cartoon series, after The Flintstones (1994), The Adventures of Rocky & Bullwinkle (2000) and Speed Racer (2008)
- This is Nicola Peltz's second live-action adaptation of a cartoon series, after The Last Airbender (2010)
- This is T.J. Miller's second live-action adaptation of a cartoon series, after Yogi Bear (2010)
- And this is Stanley Tucci's first live-action adaptation of a cartoon feature, he would later star in Beauty and the Beast (2017).
- The film is set in a future era (2015, four years after Transformers: Dark of the Moon (2011)).
- Ratchet and Lockdown know each other
- Megatron's head is online in an industrial complex and he uses human technology to reform himself.
- Lockdown, the Dinobots, a Japanese-styled Transformer and Stinger, a Bumblebee clone appear.
- Inventor Cade Yeager is based on Dr. Isaac Sumdac (both are single parents with daughters).
- Joshua Joyce is based on industrialist Porter C. Powell (both have large glasses and end up creating Decepticons).
- the Transformers on Earth are being hunted down in the aftermath of a devastating battle
- Attinger's plan of getting a government contract through man-made Transformers was taken from the Machination story arc (the Machination forms Transformers for profiteering)
- a human operative justifies his actions as necessary for protecting mankind, said actions include working with evil robots (in the comics it was Spike Witwicky, in the film it's Attinger)
- the heads of Ratchet, Sentinel Prime and Megatron in a laboratory pays homage to Sunstreaker's head being kept in a Machination lab
- Drift makes an appearance
- and the Dinobots appear as a separate faction who eventually join the Autobots.
- the story is set in a dark future
- Galvatron/Megatron is rebuilt into a new body, just like Alex Murphy and Cain
- Harold Attinger is based on Dick Jones (and Paul McDaggett): he orders a manhunt for the heroes, is simply acting to get a government contract, holds an alliance with a Decepticon, and near the end of the film holds someone hostage and gets gunned down
- Joshua Joyce is partly based on Dr Juliette Faxx: he builds a new Transformer and refers to the Autobots as outdated
- Savoy's death scene is similar to Jones' death (a fall from a building window)
- Optimus Prime acquires the ability to fly, just like RoboCop does.