| David Letterman | ... | Himself - Host | |
| Robert Pattinson | ... | Himself | |
| Annie Leibovitz | ... | Herself | |
| David Crosby | ... | Himself - Musical Guest | |
| Graham Nash | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Musical Director | |
| rest of cast listed alphabetically: | |||
| Bill Clinton | ... | Himself - 1992 Convention Speech (archive footage) | |
| Brian Donahue | ... | Brian the Alan Kalter Assaulter | |
| Newt Gingrich | ... | Himself - Texas Patriots Debate (archive footage) | |
| Alan Kalter | ... | Himself - Announcer | |
| Will Lee | ... | Himself - CBS Orchestra: Bass (as Will) | |
| Steve Martin | ... | Himself - Promoting Appearance on Friday's Show | |
| Ronald Reagan | ... | Himself - 1980 Convention Speech (archive footage) | |
| Johnny Dark | ... | World's Oldest Page | |
| Margaret Hall | ... | Lady Who Receives Flowers (uncredited) | |
| Stephanie Birkitt | ... | Herself |
| Main series | Episode guide | Full cast and crew |
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