Amy is hurt when Penny and Bernadette go bridesmaid dress shopping without her, so she turns to a reluctant Sheldon for comfort.



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Episode cast overview:


While Amy and the guys are eating lunch in the cafeteria, Howard receives a text message from Bernadette about how her wedding and bridesmaids dress shopping is going with Penny. This news hurts Amy, who feels like she has through most of her life as the shunned person by who she thought were her friends. She turns to Sheldon for support, he who is not well equipped to handle Amy's request for support. As such, he turns to Howard and Leonard to get "their women in line". Howard and Leonard find out that Bernadette and Penny did have a specific reason for not inviting Amy. Feeling like they did betray their new girlfriend, Bernadette and Penny have to come up with a way to make it up to Amy in a meaningful way, otherwise they may face the continued wrath of Sheldon. Written by Huggo

Plot Summary | Plot Synopsis


Comedy | Romance


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Release Date:

3 November 2011 (USA)  »

Company Credits

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Technical Specs


Sound Mix:


Aspect Ratio:

16:9 HD
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Did You Know?


Sheldon has always emphasized how Amy is not his girlfriend, but when a drunk Amy called him Cuddles at the parking lot, earning a frown from Leonard, Sheldon simply said "Yes, Cuddles, we cuddled. Grow up Leonard" indicating that he does not care what his friends might say regarding his relationship with Amy. See more »


In Amy's lab there is a dark green compressed gas cylinder with a "Flammable" label. Dark green is used to indicate Argon, which is not flammable. See more »


[first lines]
Penny: Bernadette, how goes the hunt for bridesmaid dresses?
Bernadette Rostenkowski: Well, if you don't mind looking like an orange traffic cone, great.
Amy Farrah Fowler: [entering] Girlfriends, I have the answer to our dress problems.
Bernadette Rostenkowski: Really?
Amy Farrah Fowler: Twelve years ago, my cousin, Irene, and her entire family died in a horrific carbon monoxide accident the night before her wedding.
Bernadette Rostenkowski: That's horrible!
Amy Farrah Fowler: Yes and no. All those bridesmaids dresses remain unused and available to us for free. So it seems that cloud of odorless deadly gas had a ...
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Crazy Credits

The usual "Chuck Lorre Productions" card has a unique photo on it this time: the Lego Star Wars Death Star II. See more »


References Star Wars: Episode IV - A New Hope (1977) See more »


Big Bang Theory Theme
Composed and Performed by Barenaked Ladies
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User Reviews

Amy feels rejected in "The Isolation Permutation" ep of "The Big Bang Theory"
21 November 2011 | by (Baton Rouge, La.) – See all my reviews

In a nutshell of this ep of "The Big Bang Theory" from this season: Because Amy keeps weirding out Penny and Bernadette when shopping for wedding dresses, she's kept out of the most recent one which makes her sad. So sad she wants Sheldon to make mad love to her. Since Sheldon is uncomfortable with the whole intimacy thing, she settles for simply cuddling which is still too much for him and which has him telling Leonard and Howard to "keep your women in line"! I'll stop there and just say Mayim Bialik keeps the dramatic and comedic side of her Amy character in a good balance as one feels for her and can still laugh at her attempts to adjust to whatever social situations she gets into. And as always, Jim Parsons just gives in to the Sheldon character in full force with hilarious results. Not a great episode but "The Isolation Permutation" is still a good enough edition of "The Big Bang Theory" to get by.

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