In a recent interview, Kevin Williamson revealed that one of the first ideas for this show was in his draft for Scream 3 (2000), the one movie of the franchise that he ended up not writing. The idea was that Sidney Prescott would arrive to a house to find a group of murdered people, implying that she was too late to save them. The twist would have been that at one moment, they would all start getting up, alive, and it would be revealed that they were all part of a cult following Ghostface.
The characters Mark and Luke, the twins in season two, are played by one actor, Sam Underwood. Every scene that they're in together had to be filmed twice and pieced together post-production. A few scenes, however, are filmed with stunt double Shan Agish switching out roles.
Jeananne Goossen was originally cast as a series regular in the role of Agent Jennifer Mason but after the pilot episode, her character was written off and replaced with Agent Debra Parker and Annie Parisse was cast.
The trivia items below may give away important plot points.
Both Bacon and Ashmore have roles in X-Men movies; Ashmore played Iceman in X-Men (2000), X2: X-Men United (2003), X-Men: The Last Stand (2006) and X-Men: Days of Future Past (2014) with Bacon appearing solely as the villain in X-Men: First Class (2009) which Ashmore does not appear in.
In episode 8 of season 1, during the conclusion of Joe's successful second prison escape and first reunion with his "Followers," the show played the opening credits song for the History Channel TV series "Vikings"
The actors playing the main villains in the first two seasons, being James Purefoy (Joe Carroll) and Connie Nielsen (Lily Gray), have both played in productions about ancient Rome: Nielsen in Gladiator (2000), and Purefoy in Rome (2005). Zuleikha Robinson, who played Gwen in season 3, also had a supporting role in 'Rome'.