After Sandy and Diane purchase the $200 car, the scene showing their arrival to St. Louis as they cross a bridge is actually downtown Chattanooga. The tallest buildings and St. Louis Arch were digitally added.
The punch that Diana uses at least twice on Sandy Patterson, and on other people in the film, is a very dangerous tactic. A punch like that in the larynx is a killing blow breaking the larynx suffocating the person.
When Sandy first arrives to Miami, Florida to catch Diana at the salon, the scene starts with an aerial zoom in of a coastline then a short cut to Sandy waiting in the car outside of the salon. The scene tries to depict Winter Park as just a short drive from Miami when in truth Winter Park is a suburban city of Orlando, FL, about a 5 hour drive outside South Beach.
Critic Rex Reed drew considerable ire when his review singled out Melissa McCarthy's weight, calling her "a hippo", "obese" and "humongous". One of his own many critics was McCarthy's frequent director Paul Feig who cordially invited Reed on Twitter to "go fuck himself".
In the scene where Sandy and Diane pull up Cornish' employment records, the computer screen shows that Cornish had Pag-Ibig no., a GSIS no., a PhilHealth no. and a TIN which are standard Philippine employment membership, benefit and tax numbers.
To many people's surprise, this opened at number one at the box office with a gross in excess of $30 million. This was quite an achievement considering that a major winter storm in the Northeast of the USA hit that weekend, forcing many roads and even theaters to close.