The name Emmanuel means "God is with us".
The string game that Lucifer is playing is called a Jacob's Ladder. In Genesis 28:10, Jacob dreams that he sees a ladder connecting heaven and earth, with angels going up and down the ladder. Mark Pellegrino (Lucifer) also played Jacob in the TV show, Lost.
Meg's face and body is noticeably swollen when her character returns. This is because her actress, Rachel Miner, had sustained a back injury while filming Caged Heat (2010), episode 10 of season 6, and was taking medication for the injury.
The title of this episode is a play with the title of the movie, "The Bourne Identity".
In this episode Dean is driving a black 1970 Dodge Charger.