The voice actors for The Amazing Spider-Man and Spider-Man 2099, Josh Keaton and Christopher Daniel Barnes respectively, were also the voice actors of Ultimate Spider-Man and Spider-Man Noir in the previous game Spider-Man: Shattered Dimensions (2010).
This game's story is written by Peter David, the co-creator of Spider-Man 2099, alongside directors Ramiro Bélanger and Gérard Lehiany.
This game was released a week after X-Men: Destiny (2011), another gamed licensed from Marvel Comics characters and released by Activision.
If players pre-order the game from Gamestop, they will be able to download all four costumes Spider-Man wore in the "Identity Crisis" story arc (Dusk, Prodigy, Hornet and Ricochet) as alternate costumes, each providing a boost in a certain attribute.
Peter Parker's Spider-Man costume retains noticeable damage as the game progresses. At one point his ear and hair are visible. Miguel O'Hara's Spider-Man costume doesn't show any damage because it's made of Unstable Molecule fabric.