After being stabbed in the heart, Alex has a profound experience in the liminal space, while a desperate Charlie and Dawn race against the clock to save her life. Meanwhile, Joel is pulled in to the ER to treat a suicidal patient that tests his duty as a doctor, and Maggie makes a bold decision that changes her relationship with Gavin.
With her body still in a coma, Alex shares an emotional journey with Charlie in the spirit world as he 'ghost-doctors' a brain-dead mother-to-be. Meanwhile, Joel forms a tight bond with a lively drug addict while trying to treat his necrotic leg. Hope Zion Hospital also welcomes its new OB/GYN, Dr. Sydney Katz, who throws Maggie off her game.
Alex is awake but still not back to her old self, and Dawn has given strict orders for her recovery plan. Meanwhile, Charlie and Joel square-off over differing treatment options when two fused-together burn victims are brought into the ER. Maggie finds herself in a whirlwind of emotions triggered from the fallout of her miscarriage.
The relationship between Alex and Joel is tested by a marathon surgery session involving an injured race-car driver. Meanwhile, Charlie has an eventful day off and a hospital "frequent flyer" keeps a number of doctors hopping.
News of Alex's pregnancy and the mystery of who the father is circles the hospital. Joel returns after his quick incarceration. Maggie studies for the board exam and deals with a patient who has a fear of doctors. Meanwhile, Alex and Dawn continue to deal with their patients in need of a heart donor.