Trivia
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Spoilers (2)
Young Dr. Franklyn in the picture Sherlock finds is actually Michael Price, one of the series' soundtrack composers.
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The quote "Once you've ruled out the impossible, whatever remains, however improbable, must be true" is used by Sherlock. A minute later Watson jokingly calls him "Spock." In Star Trek VI: The Undiscovered Country, Spock uses the same line, stating that an ancestor of his used the same quote. If this is true than Sherlock may be related to Spock.
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Russell Tovey's nephew, Nathan, auditioned to play the young Henry but was deemed to young for the part.
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Sherlock knows that Lestrade just returned from holiday because of his tan. In real life, Rupert Graves was tan because he had just returned from Guadeloupe while filming Death in Paradise. His tan was written into the script.
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In the original script, John was supposed to be driving the Land Rover with Sherlock as the passenger. But Martin Freeman does not know how to drive.
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In the original script, John was to see the hound in a meat locker. But while scouting the location, the producers determined it would be too expensive to film there and too cold for Freeman.
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When offered a cup of tea, Sherlock replies that he'd need something stronger - 7% stronger. The original Sherlock Holmes used a 7% solution of cocaine when he didn't have a case and "wanted to stimulate his mind."
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Clive Mantle was also in 'Without a clue (1988)'_, a movie re-telling of Sherlock Holmes.
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Spoilers
Russell Tovey plays a victim who is haunted by a giant "Hound" which eventually is revealed to be partly in his head. In Being Human, Tovey is also a werewolf.
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In the original script, Dr. Mortimer was to be killed by Henry but this idea was discarded.
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