A soft-spoken musician who feels abused by her cat and ashamed that she can't figure out how to stop it; A family afraid to furnish their house because the cat they rescued from Katrina stricken New Orleans, is spraying the house and dividing the family.
Jackson must rescue Meki and Megan from their cycle of co-dependency before they're both kicked out of Megan's parent's place, or worse; Jackson tutors a bouncer on how to handle his sweet Tasmanian devil of a cat; a couple shetlers special needs cats.
Jackson works with a cat, Skylar, who's literally afraid of her tail; Jackson also meets up with a pair of guardians whose cat is constantly knocking things over, climbing up the window screens, and spontaneously attacking; a handicap cat inspires people.
Jackson enters Ellen's world, one that's crawling with neighborhood feral cats, who she's been feeding and trying to contain virtually by herself for 20 years; a pair of hairless Donskoy cats who are treating their guardian's home like it's a party zone.
Jackson encounters Samantha, who fears her cat, Spike, so much she's been keeping him in a cat box outside her house; Jackson makes his way to Brooklyn where a couple are seeing their relationship suffer over the ongoing blood feud between their two cats,
Jackson visits New York City to meet a father and son who've been taking care of a feral cat colony in their backyard and are desperately in need of help; Jackson lends his expertise to Mike and Darcy, who are dealing with an antisocial cat.
For the first time on the show Jackson helps a cat that can't get along in its rescue home move in with a foster family, who he's hopeful will adopt; In My Cat From Heaven, Jackson meets Lil' Bunny Sue Roux, who has thousands of Instagram followers.