In the opening scene, one of the callers into the 911 centre states "I think I'm having an overdose and so is my wife" - the line made famous by Edward Sanchez, a policeman who confiscated marijuana from a suspect and then made brownies with it. He called 911 when he thought he had taken too much.
Halle Berry was initially cast in the lead role with Joel Schumacher directing. Schumacher dropped out and was replaced by Brad Anderson. Berry dropped out due to scheduling conflicts but once the start date was pushed up, she returned in the lead role.