Director Marc Webb chose to shoot on 35mm film instead of the digital Red Epic cameras the original was shot with. While it is relatively common for franchise films to shoot on film and transition to digital for sequels as digital cinematography and 3D has become more commonplace (e.g. Resident Evil: Afterlife (2010), Skyfall (2012), Iron Man 3 (2013), Pirates of the Caribbean: On Stranger Tides (2011)) this is a rare example of a franchise switching to film after being shot on digital.
Marc Webb had a two-picture contract with Twentieth Century Fox, which he partially fulfilled by directing (500) Days of Summer (2009). The second feature would have conflicted with his schedule for directing this film. To be released from that obligation long enough to shoot this film, Webb had to agree to extend that contract to three pictures. It is currently unknown if he will be able to direct the 3rd and 4th films in the series.
Two display cases in Oscorp feature a set of metal wings, and an exoskeleton holding four arms. These are homages to Spider-Man's antagonists the Vulture (Adrian Toomes) and Doctor Octopus (Otto Octavius).
Paul Giamatti loved the Russian accent he used for Aleksei Sytsevich: "He's a Russian mobster. Russians are always good villains. My accent is pretty hammy. It seemed to me like an opportunity to be as over-the-top hammy as possible. It was really fun."
The trivia items below may give away important plot points.
The film's portrayal of Electro combines the classic Marvel Comics character (mild Maxwell Dillon, who acquires superpowers in an accident and goes insanely villainous) with the Marvel "Ultimate" character (a leather-clad supervillain).