After asking Cuddy to do something illegal, House starts to leave her office and says, "North, Miss Teschmacher!" to Dominika. Miss Teschmacher was Lex Luthor's assistant in Superman (1978), played by Valerie Perrine. House is basically alluding to being an evil genius like Lex Luthor with Dominika as his assistant. House also sarcastically tells the patient he must be a superhero, asking him "What color is my underwear?", which is what Lois Lane asked Superman in the same movie when she was testing his x-ray vision.
Reunites Christopher Rodriguez Marquette and Amber Tamblyn, former co-stars of the series Joan of Arcadia (2003).
House's comment, "Since I'm assuming 'Ferris Bueller' is not his real name," upon reading the patient's admission form, refers to the movie Ferris Bueller's Day Off (1986), which chronicles the adventures of a determined high school senior intent on ditching school for a day.