Rosalee goes missing after a band of orphaned children target her as the mother figure they have always wanted. With a furious Monroe by their side, Nick and Hank race against the clock to find Rosalee.
Monroe is in danger when Wesen business owners are targeted in a string of attacks being investigated by Nick and Hank. Trouble catches Nick and Adalind up on her recent activities. Captain Renard endorses a political candidate.
After surviving a wesen ambush from a terrorist cell known as the Black Claw, Nick discovers "Juliette" is still alive, but learns what Chavez and Meisner were doing to her. The group interrogate Xavier. The group soon learns these attacks go beyond Portland. An attack occurs at the Wesen Council.
The legend of the Lake Monster comes back to life as Nick (David Giuntoli) and Hank (Russell Hornsby) investigate a mysterious sighting linked to a tourist's death at a local lake. Rosalee's (Bree Turner) past comes back to haunt her. Elsewhere, Capt. Renard (Sasha Roiz) continues to support a candidate for mayor. Meanwhile, Nick is shown the scope of the Wesen uprising as the secret government agency takes him into the heart of their Portland operations center.
Nick and Hank race against time to prevent the completion of an ancient Wesen ritual that requires seven sacrificial murders. Meisner, Trubel, and Eve track a suspected Black Claw agent's arrival in Portland.
Nick and Monroe discover the hidden treasure in the Black Forest. A figure from Rosalee's past comes back to haunt her. The hexenbiest suppression on Adalind begins to wear off. Renard, Hank, and Wu hunt down an assassin.
A down on his luck Luchador receives a special mask that will make him the star he's always wanted to be. Misuse, however, leads to terrible consequences. Meanwhile, Eve believes something is amiss with Dixon's assassination.
A beauty regimen proves deadly for a young woman, who seems to have aged 70 years when Nick and Hank find her lifeless body. As they search for proof of Wesen involvement, they are led to a local doctor, and end up enlisting Rosalee's help in their investigation. Meanwhile, Eve takes a bold step to learn more about Capt. Renard's nefarious dealings.
Nick investigates a traveling preacher who uses his wesen identity to gain followers after one of his bodyguards winds up dead, while a religious sect is seeking to capture him. Eve uses Renards body to further investigate the Black Claw.
When a man is found dead with all of the bones in his body seemingly liquefied and removed, Nick and Hank find themselves in the middle of a gruesome family arrangement. Meanwhile, Wu deals with a crisis of his own and Hank reunites with his old flame, Zuri.