Damon Wayans Jr. was originally a cast member playing the character of Coach. Wayans was expecting his series, Happy Endings (2011), to be canceled. But when that series was renewed, Wayans was unable to continue with this series after the pilot. He was replaced with Lamorne Morris as Winston. After Happy Endings (2011) was canceled, Wayans was able to return to this series in the third season.
Windows can be seen in Nick's room as well as Winston's, but that is not realistic since the floor plan of the loft should have Nick's room sharing a wall with the hall and Winston's room sharing a wall with the hall and another loft since it's in the corner of the loft.
In one episode Jess starts to give Nick the PIN code for her ATM card, which begins with 4 and 2. Zooey played Trillian in "The Hitchhiker's Guide to the Galaxy" which is based on a series of books in which the number 42 plays a significant role.
David Walton played Jess's boyfriend, Sam, who we find out is a children's doctor. In 2014, David was given his own show, About a Boy (2014), in which his character dates a children's doctor named Dr. Sam.
In season two when Sam breaks up with Jess, she cries on the couch and says she just wants to listen to Taylor Swift songs. Taylor Swift later appears in an episode playing a character and not herself.
Both Zooey Deschanel and Jake Johnson have portrayed school principals. Johnson played Principal Dadier in 21 Jump Street (2012) while Deschanel became a Vice-Principal in the 3rd season of _New Girl_ and a Principal in the 6th season.