| Queen Latifah | ... | Herself - Host |
| rest of cast listed alphabetically: |
| Quinton Aaron | ... | Himself |
| Malin Akerman | ... | Herself - Presenter, Favorite Movie Actress |
| Jennifer Aniston | ... | Herself - Presenter, Favorite Comedic Star |
| Diedrich Bader | ... | Himself |
| Fileena Bahris | ... | Herself |
| Ashley Bell | ... | Herself |
| Jimmy Bennett | ... | Himself |
| Ashley Benson | ... | Herself |
| Pippa Black | ... | Herself |
| David Boreanaz | ... | Himself |
| Julie Bowen | ... | Herself - Presenter, Favorite Female Artist |
| Deuandra T. Brown | ... | Herself |
 | Ellen R. Brown | ... | Herself |
| Mireya S. Brown | ... | Hersef |
| Sarah Alice Burns | ... | Herself - Dancer |
| David Burtka | ... | Himself |
| Hector Luis Bustamante | ... | Himself |
| Parvesh Cheena | ... | Himself |
| Michael Chiklis | ... | Himself - Presenter, Favorite Female Artist |
| Chris Colfer | ... | Himself |
| Miranda Cosgrove | ... | Herself - Presenter, Favorite Movie Star Under 25 |
| Kaley Cuoco | ... | Herself |
| Cat Deeley | ... | Herself |
| Johnny Depp | ... | Himself - Winner, Favorite Movie Actor |
| Emily Deschanel | ... | Herself |
| Sacha Dhawan | ... | Himself |
| Diddy-Dirty Money | ... | Themselves |
| Taye Diggs | ... | Himself - Presenter, Favorite TV Comedy Actor and Actress |
| Lisa Edelstein | ... | Herself - Winner, Favorite TV Drama Actress |
| Zac Efron | ... | Himself - Winner, Favorite Movie Star Under 25 |
| Lyndsy Fonseca | ... | Herself |
| Selena Gomez | ... | Herself |
| Kathy Griffin | ... | Herself |
| Neil Patrick Harris | ... | Himself - Winner, Favorite TV Comedy Actor |
| Teri Hatcher | ... | Herself |
| Darrin Dewitt Henson | ... | Himself |
| Tiffany Hines | ... | Herself |
| Kendall Jenner | ... | Herself |
| Kylie Jenner | ... | Herself |
| Elton John | ... | Himself |
| Khloé Kardashian | ... | Herself |
| Kim Kardashian | ... | Herself |
| Kourtney Kardashian | ... | Herself |
| Minka Kelly | ... | Herself |
| Kid Rock | ... | Himself |
| Daralina Komar | ... | Dancer |
| Mila Kunis | ... | Herself - Presenter, Favorite Talk Show Host |
| Ashton Kutcher | ... | Himself - Presenter, Favorite Movie |
| Hugh Laurie | ... | Himself |
| Taylor Lautner | ... | Himself |
| Kim Lee | ... | Herself |
| Meisha Lee | ... | Dancer |
| Zachary Levi | ... | Himself - Presenter, Favorite TV Drama Actress |
| Liz Leyda | ... | Herself |
| Jane Lynch | ... | Herself - Winner, Favorite TV Comedy Actress |
| Bailee Madison | ... | Herself |
| Rizwan Manji | ... | Himself |
| Mahaley Manning | ... | Herself (as Mahaley Hessam) |
| Jessica Maybal | | |
| Matt McAbee | ... | Himself |
| AnnaLynne McCord | ... | Herself - Presenter, Favorite TV Guilty Pleasure |
| Candace McKinney | ... | Herself |
| Leighton Meester | ... | Herself |
| AJ Michalka | ... | Herself |
| Aly Michalka | ... | Herself |
| Cory Monteith | ... | Himself |
| Stephen Moyer | ... | Himself - Presenter, Favorite Movie Actress |
| Anisha Nagarajan | ... | Herself |
| Conan O'Brien | ... | Himself - Winner, Favorite Talk Show Host |
| Jerry O'Connell | ... | Himself - Presenter, Favorite TV Guilty Pleasure |
| Nancy O'Dell | ... | Herself |
| Brian Palatucci | ... | Himself - Presenter, Favorite Viral Video Star |
| Jim Parsons | ... | Himself - Presenter, Favorite Movie Star Under 25 |
| Pauley Perrette | ... | Herself - Presenter, Favorite New TV Drama and Comedy |
| Katy Perry | ... | Herself - Winner, Favorite Female Artist and Favorite Online Sensation |
| Drew Pinsky | ... | Himself (as Dr. Drew) |
| Natalie Portman | ... | Herself - Presenter, Favorite Movie |
| Maggie Q | ... | Herself |
| Lena Ramok | ... | Dancer |
| Ben Rappaport | ... | Himself |
| Raven-Symoné | ... | Herself |
| Emma Roberts | ... | Herself - Presenter, Favorite TV Drama Actress |
| Adam Sabbagh | ... | Himself |
| Adam Sandler | ... | Himself - Winner, Favorite Comedic Star |
| The Scene | ... | Themselves - Performers |
| Rob Schneider | ... | Himself |
| William Shatner | ... | Himself |
| David Spade | ... | Himself |
| Michael Anthony Spady | ... | Himself |
| Kristen Stewart | ... | Herself - Winner, Favorite Movie Actress |
| Taylor Swift | ... | Herself - Winner, Favorite Country Artist |
| JoAnna Garcia Swisher | ... | Herself (as Joanna Garcia) |
| Niki Taylor | ... | Herself |
| Bobbie Thomas | ... | Herself - Fashion Correspondent |
| Bella Thorne | ... | Herself |
| Ashley Tisdale | ... | Herself |
| Robert Verdi | ... | Himself - Fashion Correspondent |
| Kate Walsh | ... | Herself - Presenter, Favorite TV Comedy Actor and Actress |
| Shane West | ... | Himself |
| The Whittaker Family | ... | Themselves - Winner, Favorite Viral Video Star |
| Vanessa Williams | ... | Herself |
| Virginia Williams | ... | Herself |
company.