Though not directly referenced, the Motch brothers are based on the real life Koch brothers. David H. Koch and Charles G. Koch are major contributors to conservative policy and advocacy groups in the U.S.
WWE wrestler Mike 'The Miz' Mizanin had filmed a scene where he would introduce Cam Brady (Will Ferrell) but the scene was later dropped before the movie's premiere. However he can be still seen in the background in a later scene.
Although the poster depicts the two lead characters facing off in from Capitol Hill in Washington, D.C., almost the whole film is set in and around North Carolina where the two characters live and are campaigning. There is a single post-credit sequence set in Congress.
During the end credits when Marty Huggins (Zach Galifianakis) is mentioning the aliases used by Tim Wattley (Dylan McDermott), one of the names he says is Dermot Mulroney. In real life, McDermott is sometimes confused with Mulroney due to the similarities in their names.