An off-brand acne cream gives Napoleon intense strength. Soon the gym teacher recruits him for a secret fight club and his brother Kip, who usually has the upper hand, doesn't like his brother's new sense of power.
When Professor Koontz uses a scantron machine to pair students romantically, Napoleon is matched with Tokiko, the Japanese exchange student, a disappointed Deb is paired with bully Don Moser and Pedro is happily paired with Don's girlfriend Summer Wheatley. Don's mother and sisters take Deb under their wings, which she reluctantly allows until she discovers they have ulterior motives.
Napoleon takes an after school job at a farm that raises his favorite mystical creature: the Liger. But the half tiger/half lion animal doesn't seem as awesome in real life as it did in his notebook doodles.