This film is inspired by various comic books and superhero movies. After this film's release, cast members Dane DeHaan and Michael B. Jordan went on to star in big-budget superhero films. DeHaan played Harry Osborn/Green Goblin in The Amazing Spider-Man 2 (2014) and Jordan went on to play Johnny Storm in Fantastic Four (2015).
The trivia items below may give away important plot points.
The filmmakers originally intended to have Andrew splay and tear apart his father's limbs exactly like the spider's, but the scene was removed to preserve a PG-13 rating, and to showcase Matt's pacifistic nature.
During the high school talent show Andrew walks on to the stage through a stylized painting of The Cave of Wonders from Disney's Aladdin (1992). This is meant to represent the mysterious cave where the trio received their powers.