In the Men's singles many of seeded players made it through led by 2009 finalist Robin Söderling, Mikhail Youzhny and Marin Cilic. While Jo-Wilfried Tsonga was pushed to the limit by German Daniel Brands as he came through 7-5 in the fifth. Tsonga was joined by compatriots Édouard Roger-Vasselin, Josselin Ouanna and Julien Benneteau who upset 23rd seed Ernests Gulbis 6-4, 6-2, 1-0 as Gulbis retired with a hamstring injury.
In the Women's side 6th seed and defending champion Svetlana Kuznetsova cruised through the first round with a 6-3, 6-1 victory of Sorana Cîrstea. She was joined by 2nd seed Venus Williams, Madrid champion Aravane Rezaï, Nadia Petrova, Flavia Pennetta, Maria Kirilenko and last years Semifinalist Dominika Cibulková. The day featured two upsets. Victoria Azarenka, hindered by an injury and only appeared in the event to have entered to claim the bonus prize money for ending the 2009 season in the top 10, became the first major casualty of the tournament as she was upset by Gisela Dulko. Rome champion María José Martínez Sánchez was also upset by Akgul Amanmuradova.
In the Men's Singles World no. 1 and defending champion Roger Federer cruised past Peter Luczak with a 6-4, 6-1, 6-2 victory. He was joined by Indian Wells champion Ivan Ljubicic, Miami finalist Tomás Berdych, Stan Wawrinka, John Isner and Thomaz Bellucci. While World no. 3 Novak Djokovic, last years semifinalist Fernando González, Gael Monfils and Victor Hanescu all won in 4. While world no. 4 Andy Murray took on Richard Gasquet and won 4-6, 6-7, 6-4, 6-2, 6-1. 29th seed Spaniard Nicolás Almagro also needed five sets to defeat Robin Haase. The upsets of the day saw Spanish clay courters Feliciano López and Tommy Robredo both fall.
In the Women's draw 6 of the top 8 seeds were in action and all won. The field was led by World no. 1 Serena Williams who beat Stefanie Vögele 7-6, 6-2. She was joined by Caroline Wozniacki, Jelena Jankovic, Elena Dementieva, Samantha Stosur and Aga Radwanska. Other seeds Li Na, Kateryna Bondarenko, Alisa Kleybanova and Lucie Safárová who defeated Jelena Dokic all won in straight sets. While Francesca Schiavone and Alona Bondarenko come back from a set down to get to the second round.
Day 3 of action was led by 4-time champion and 2nd seed Rafael Nadal who defeated Gianni Mina 6-2, 6-2, 6-2. Nadal was joined by fellow Spaniards 7th seed Fernando Verdasco, 16th seed Juan Carlos Ferrero, 9th seed David Ferrer and Pere Riba. Other seeds who went through were German Philipp Kohlschreiber, Austrian Jürgen Melzer and former world no. 1 Lleyton Hewitt. While 6th seed Andy Roddick who was playing his first match in clay of the season needed 5 sets to get past Jarkko Nieminen 6-2, 4-6, 4-6, 7-6, 6-3. Upsets were not avoided as two seeds fell in 4. As 18th seed Sam Querrey lost to compatriot Robby Ginepri and 26th seed clay courter Juan Mónaco was upset by Grega Zemlja.
In the Women's Singles almost all seeds got through in straight sets led by Justine Henin who beat Tsvetana Pironkova 6-4, 6-3, in her 1st match at RG for 3 years. She was joined by unseeded compatriots Kirsten Flipkens and Yanina Wickmayer, as well as Russians Maria Sharapova, Vera Zvonareva and Anastasia Pavlyuchenkova. Other seeds Daniela Hantuchová, Shahar Pe'er, Zheng Jie and Frenchwoman Marion Bartoli all won. The second major upset of the tournaments came at the cost of 2 time finalist Dinara Safina who was upset by 39-year-old Kimiko Date-Krumm 3-6, 6-4, 7-5.
Roger Federer dispatched Colombian Alejandro Falla in straight sets. Other straight sets victors were Robin Söderling, Jo-Wilfried Tsonga, Marin Cilic, Tomás Berdych, Stan Wawrinka and Albert Montanés. While Mikhail Youzhny progressed in four after losing the first set tie-break. The only upset of the day was when Thiemo de Bakker defeated 32nd seed Guillermo García-López. The end of the day saw lots of matches being suspended and canceled due to rain delays. One of those matches was between Frenchman Gael Monfils and Italian Fabio Fognini which descended into chaos as they played on despite extreme darkness for 2 games, before finally coming off court a full 25 minutes after Murray and Chela's match did, at 5-5 in the 5th.
Venus Williams led the days games in the women's side with a 6-2, 6-4 victory over Arantxa Parra Santonja, she was joined by Caroline Wozniacki, Flavia Pennetta, Nadia Petrova, Alexandra Dulgheru and Maria Kirilenko who all won straight sets. While Dominika Cibulková and Aravane Rezaï scrambled to win in three. One of the stories of the day was with defending champion Russian Svetlana Kuznetsova against German Andrea Petkovic, who served for the match in the 2nd set, but the Russian survived 4-6, 7-5, 6-4. As with the Men's side several matches were canceled.
Roger Federer lost his quarterfinals match against Robin Söderling, making it the first time since the 2004 French Open that Federer did not reach at least the semifinals of a Grand Slam tournament. It also meant that Federer lost his ATP men's single No. 1 ranking in tennis since Rafael Nadal won the 2010 French Open men's singles title. Also, since Nadal became the 2010 French Open men's singles champion, Federer was left only one week short of equaling Pete Sampras's record number of 286 weeks as the ATP No. 1 ranked men's singles player.
Rafael Nadal reclaimed the No. 1 men's singles ATP ranking, leaving Roger Federer only one week short of equaling Pete Sampras's record number of 286 weeks as the ATP No. 1 ranked men's singles player. This win is also the first time since the French Open 2004 that Roger Federer was knocked out by a player who hasn't won a grand slam tournament.
Rafael Nadal's victory also completed a historic 'Clay Slam' for Nadal, seeing him become the first person in history to win all Masters 1000 tournaments on clay (Monte Carlo, Rome and Madrid), as well as the French Open, in the same calendar year.
The Williams sisters won their 12th Grand Slam doubles title and 2nd at the French Open. With this, they hold all Grand Slam doubles titles simultaneously. Also, they have won the career women's doubles golden slam for the second time in their respective careers.