At one point in the movie, Ted mentions 9/11. Mark Wahlberg and Seth MacFarlane both narrowly missed being on one of the planes that hit the World Trade Center. Wahlberg was booked on American Airlines Flight 11 but decided to drive down to New York and fly to California later. MacFarlane was scheduled on the same flight but arrived at the gate ten minutes late and was unable to board. He was sitting in the airport when he saw that his plane had hit the WTC North Tower.
"007" producer Barbara Broccoli traditionally never allows any James Bond theme to be used in other films, but Seth MacFarlane wrote her a letter asking for permission to use "All Time High" from Octopussy (1983) as it was his mother's favorite song. Broccoli made a rare exception to her rule, hence John gets to slaughter the tune in a performance in front of a dismayed crowd.
DIRECTOR TRADEMARK (Seth MacFarlane): (Family Guy): Several of the main voice cast of Family Guy (1999) had parts in this movie. Seth McFarlane, who voiced Ted (and wrote and directed this film) voices Peter, Stewie, and Brian. Alex Borstein, who plays John's mom, provides the voice for Lois. Mila Kunis, who plays Lori, is the voice of Meg. The only main Griffin family member not to appear in the film is Seth Green, who voices Chris. Other Family Guy (1999) regulars that appear in Ted (2012), include Patrick Warburton, Sir Patrick Stewart, and Ralph Garman. Jessica Stroup provided the voice of Denise in three episodes of Family Guy (1999), and also appears in this film.
According to Seth MacFarlane, this is the first comedy film to use motion capture technology. However, the comedy film Paul (2011) used motion capture technology as well, and it was released a year earlier than Ted (2012).
An actual teddy bear doll was used for filming with Seth Macfarlane also voicing Ted's dialogue live. The rationale for this, as opposed to using a much easier green screen approach, was that he wanted to get the cast's genuine reaction to what Ted was doing, as opposed to them having to imagine it.
When Lori gets back home and finds Ted watching television with some hookers, one of the films seen on the television menu is Dead Silence (2007), which stars Mark Wahlberg's older brother, Donnie Wahlberg.
Ted and John's friendship is similar to Winnie the Pooh and Christopher Robin. Winnie was based on an old plush bear, originally named Edwin, that A.A. Milne gave his son, Christopher Robin, in 1921, for his first birthday.
The film was originally scheduled for release on July 13, 2012, but was moved up to June 29, the original intended release date of G.I. Joe: Retaliation (2013), which had been pushed back to March 29, 2013 for re-shoots.
Before his ringtone was changed to the Knight Rider (1982) theme, the music heard on John Bennett's cellphone (when it fell between the car door panel and the seat) is the Imperial March from Star Wars.
In the final scene, the narrator, voiced by Sir Patrick Stewart, trashes Superman Returns (2006). This may be an in-joke to Bryan Singer, who directed Superman Returns (2006), and directed Stewart in several X-Men movies.
At the end of the movie, the narrator states that Sam J. Jones moved in with Brandon Routh. Both actors starred in a movie as the title characters based on a comic book, with Jones in Flash Gordon (1980) and Routh in Superman Returns (2006). There were plans for a follow-up to both films, but they were scrapped when their studio was disappointed with their box office gross despite having a warm reception from fans and critics.
After getting his ear ripped off, Ted escapes through a door only to reach back and grab his ear. The theme for Indiana Jones can be heard as he does it, as this is a trademark of Jones: losing his hat and reaching to grab it at the last minute.