At one point in the movie, Ted mentions 9/11. Mark Wahlberg and Seth MacFarlane both narrowly missed being on one of the planes that hit the World Trade Center. Wahlberg was booked on American Airlines Flight 11 but decided to drive down to New York and fly to California later. MacFarlane was scheduled on the same flight but arrived at the gate ten minutes late and was unable to board. He was sitting in the airport when he saw that his plane had hit the WTC North Tower.
"007" producer Barbara Broccoli traditionally never allows any James Bond theme to be used in other films, but Seth MacFarlane wrote her a letter asking for permission to use "All Time High" from Octopussy (1983) as it was his mother's favorite song. Broccoli made a rare exception to her rule, hence John gets to slaughter the tune in a performance in front of a dismayed crowd.
DIRECTOR_TRADEMARK(Seth MacFarlane): [Family Guy]: Several of the main voice cast of Family Guy (1999) had parts in this movie. Seth McFarlane, who voiced Ted (and wrote and directed this film) voices Peter, Stewie, and Brian. Alex Borstein, who plays John's mom, provides the voice for Lois. Mila Kunis, who plays Lori, is the voice of Meg. The only main Griffin family member not to appear in the film is Seth Green, who voices Chris. Other Family Guy (1999) regulars that appear in Ted (2012) include Patrick Warburton, Patrick Stewart, and Ralph Garman. Jessica Stroup provided the voice of Denise in three episodes of Family Guy (1999) and also appears in this film.
According to Seth MacFarlane, this is the first comedy film to use motion capture technology. However, the comedy film Paul (2011) used motion capture technology as well, and it was released a year earlier than Ted (2012).
In a flashback to 2008, John says, "Chris Brown can do no wrong" as a foreshadowing of what happened in 2009 when Brown was arrested for assault after physically assaulting and beating his girlfriend Rihanna.
An actual teddy bear doll was used for filming with Seth Macfarlane also voicing Ted's dialogue live. The rationale for this, as opposed to using a much easier green screen approach, was that he wanted to get the cast's genuine reaction to what Ted was doing, as opposed to them having to imagine it.
Ted and John's friendship is similar to Winnie the Pooh and Christopher Robin, who were a bear and person, respectively. Christopher Robin was based on a real boy named Christopher Robin and Winnie was based on an old teddy bear originally "Edwin" bear that was given as a first birthday gift to Christopher Robin by his father A.A Milne in 1921.
The film was originally scheduled for release on July 13, 2012, but was moved up to June 29, the original intended release date of G.I. Joe: Retaliation (2013), which had been pushed back to March 29, 2013 for re-shoots.
Before his ringtone was changed to 'Knight Rider' theme, the music heard on John Bennett's cellphone (when it fell between the car door panel and the seat) is of Star wars 'Darth Vadar' entrance piece.
In the final scene, the narrator, voiced by Patrick Stewart, trashes Superman Returns (2006). This may be an in-joke to Bryan Singer, who directed Superman Returns (2006) and directed Stewart in several X-Men movies.
At the end of the movie, the narrator states that Sam J. Jones moved in with Brandon Routh. Both actors starred in a movie as the title characters based on a comic book, with Jones in Flash Gordon (1980) and Routh in Superman Returns (2006). There were plans for a follow-up to both films, but they were scrapped when their studio was disappointed with their box office gross despite having a warm reception from fans and critics.
After getting his ear ripped off, Ted escapes through a door only to reach back and grab his ear. The theme for Indiana Jones can be heard as he does it, as this is a trademark of Jones: losing his hat and reaching to grab it at the last minute.
Mark Wahlberg's character John was originally supposed to be crying while screaming for Ted when he died at the climax, and while he was supposed to come back, Director Seth MacFarlane felt the scene was too depressing and was cut.