In "The 21-Second Excitation" Bernadette says that Howard has one long hair on his chest, however, in "The Alien Parasite Hypothesis" when Howard is attempting to wrestle, his leotard shows off his very hairy chest.
At around 12 minutes, Sheldon answers Penny's crank call on his iPhone, but when he puts the phone to his ear it is obvious that the phone is in the lock screen rather than receiving a call. When an iPhone is put to one's ear the screen automatically turns off.
It's never been proven heat alone can kill a prion. In hospitals instruments, bedding, most anything that comes in contact with body fluids from a patient with a confirmed prion disease are thrown out. This is because there's no known way to sterilize anything contaminated with prions. They are as near to immortal as any organism.
The goof item below may give away important plot points.
When Sheldon wants to rain on Wil Wheaton's parade at the movie, he steals the two carrying cases that the film reels arrived in. When he's seen by Wheaton, he and the rest of the theatergoers give chase. However, these cases weigh about 70 pounds (32 kg) each, and are difficult to even walk with, much less run from an angry mob with.