A number of "body farms" where cadavers are subject to various decomposition scenarios for research do exist in the United States. As of 2011, there are four universities with operating body farms: the University of Tennessee at Knoxville; Western Carolina University in Cullowhee, NC; Texas State University-San Marcos; and Sam Houston State University in Huntsville, TX. A fifth facility is being created at California University of Pennsylvania in California, PA. The body farm near the St. Regis River in New York as well as the nearby University of Hogansburg are both fictional.
When Angela is hanging up pictures of the bodies to which the feet belong, the pictures of the corpses are all from previous episodes. The first three are from "A Boy in a Tree", "The Man in the Fallout Shelter", and "Two Bodies in the Lab", respectively.
The establishing shot of the fictional University of Hogansburg is in fact the Valley Life Sciences Building at UC Berkeley.
In 2007, disembodied feet actually started washing up on Canadian shores, but usually in British Columbia and occasionally Seattle, WA.
David Ury plays a character named Larry Wolfram. This is a reference to the demonic law firm Wolfram & Hart (wolf, ram and hart) in The David Boreanaz series Angel and the general Buffy-verse of Joss Whedon.