Jimmy is delighted when he finally meets fellow single father in the supermarket, so he agrees with Justin their kids should get play dates, despite lack of support on the Chase home front. It turns out Justin's far less dysfunctional family is also snobbish, end employs Virginia as cleaner. A last chance dinner backfires.
Jimmy lets hygiene-obsessed Sabrina and her detection use of the store's black-light to identify counterfeit banknotes convince him germs are an omnipresent health treat. Faced with bright blue proof all over the house, the Chances start cleaning like mad, only to find mad Maw Maw undoes it all in no time. Residential care being out of budgetary reach, they move her into the greenhouse, which goes quite well. However comparing family histories with Sabrina after watching family movies changes views.
The Chances get caught in Virginia's web of lies when her cousin Delilah, whom she told Maw-Maw was dead, turns up to claim her share of the estate, her business being wiped out by the crisis. Their rivalry started when Delilah, who was spoiled and better at everything else, lost most desirable teenager Burt to jealous Virginia, so she proposes an alternative mode of payment: in 'bedroom' kind. Jimmy was to mind the 'deceased' inconspicuously, but she escapes and crashes back in.
Barely reconciled with having to help care for Jimmy's baby, Burt and Virginia realize their unsafe sex is no longer acceptable. Burt defends his manhood but is outvoted, so Jimmy drags him to Dr. Burwitz for a vasectomy and patiently humors him to get the surgery done. In the process Jimmy discovers Burt's fear for infertility stems from worries whether Jimmy will outgrow being 'his boy'. Meanwhile Virginia warns Sabrina it's only a matter of time until she'll betray her secret to the boys, but volunteers a secret of her own to be 'blackmailed' in line.
The Chances prepare to host once more Burt's cousin Mike, a hopeless loser even by their standards. Yet they find him a changed man, as neat member of a loony sect, one of Tanya's four 'brother-husbands'. Jimmy is inadvertently attracted by their neat, apparently harmonious 'fraternity'. Alas, Mike is 'divorced' and moves in whining and desperate, worse then ever. Burt has another confrontation with his brother Bruce, who wants help to get his son Mike back and gets it after explaining why he threw the boy out years ago.
Realizing the three adult Chances are klutzes and a danger to themselves, Jimmy worries whether Hope will be taken care of after an accident. After an attempt to have them teach each other 'survival tricks' collapses in bickering, Jimmy drags his parents to dodgy lawyer Wally Phipps, who inspires including a fourth potential guardian, Sabrina. Actually she's afraid of the responsibility, and Burt is offended that she ranks higher. Their survival skills are tested frightfully realistically when an armed Maw Maw mistakes them all for 'dangerous mongooses'.
Jimmy hopes gullible Sabrina's boyfriend Wyatt may be cheating on her in college, so he insists to go with her to Wyatt's frat's wild costume party, but conclusive evidence is perilously hard to find. In order to have contact with generation peers, Maw Maw goes to Dead Tooth's daycare. She falls for a man who also lives in the past, but that includes an affair with another crone, supposedly from his Korean War days.
Jimmy's initial shrugging of sneers not to pick up Hope whenever she cries turns after his parents explain the theory his sissy shyness stems from a youth of blindly trusting in parental rescue from every danger. Now Burt must give Hope 'sleep training', for which the handbook may not suffice. Jimmy, who couldn't bring himself to be so cruel, meanwhile is dragged along by his depraved ex Zoe to a party where he consumes a space drink, which ends up inducing utter panic, but his parents stick to their recent resolve not to kill their offspring with kindness any more.
Supermarket branch manager Barney tells the team he lost out each year 'despite best ideas' in the chain's annual commercial competition, so now he wants Jimmy and his colleagues to compete for this year's submission, but flattery and considerations like fair-play and team spirit get in the way. As Hope's baby-phone accidentally tunes into a neighboring house's, ear-dropping Burt discovers Andrew is being grossly abused by his tyrannical, impossible to please wife Donna and wants to help. Virginia is reluctant to risk being seen as a nosy neighbor, but agrees to help ...
Jimmy doesn't mind at 23 sharing his birthday with Maw Maw, although it was hell as a kid, when she had lots of friends and he none. When he turned 18, in his impertinent Goth period (alias 'Drakkar Noir'), she 'finally' felt able to throw the Chances trio out of her home, so they had to grow up suddenly, seeking real job incomes supplemented by devious ways to skin the supermarket. Five years ago however, her mind went, so they got the house back with her as senile resident hazard.
Watching his 13-year-old self play the piano and singly beautifully, on home video, Jimmy sees through the claim that it was just a pianola, now broken. Virginia owns up to feeling guilty for having strangled Jimmy's talent, estranging him from his schoolmates, until a golf club from the air knocks Jimmy down and the musical talent out of him, later the subject of another confession. After consulting Dr. Finklestein, the Chances try to reconstruct the past, including Maw Maw's cruel and unorthodox tutoring methods, hoping Jimmy's memory may be restored. It seems to do...
Burt accidentally discovers that Sabrina's father Cap is really rich and tells the home front. They now hope to 'coach' her into sharing some of the Collins wealth, but she replies to have chosen to earn her own, modest income at the supermarket, an insane waste beyond the needy, greedy Chances' comprehension. Eager for rich friends, Jimmy convinces her to take him and his parents along to her sister's engagement party. Cap takes to Jimmy, who sides with him against her petty class struggle insults. As a reward, he sends a Japanese smart toilet like Virginia adores, ...
Jimmy is envious of Sabrina's smart-phone, yet anxious to sabotage a message on it from 'rival' Wayne. To Jimmy's surprise, Virginia 'welcomes' pony-tailed hippie Jack by knocking him unconscious with a portable TV as Burt's kidnapper twenty years ago, but Burt protests and confesses that the kidnapping was a scam; he set it up to spend some careless time traveling without 'chain and bolt'. Also surprising Burt, Virginia confesses that she gradually enjoyed protection and 'comfort' from measly cop Ross enough to consider a proposal from him just when Burt's return (...
Virginia's nemesis, spoiled cousin Delilah, invites the whole family to Las Vegas for her high-profile wedding with an air force hero. Jimmy asks Sabrina along, as she always wanted to 'go wild once'. Burt is allowed to come but without cash, given his gambling record. Instead he and Jimmy earn cash doing odd and dubious jobs, but make a pittance. Virginia fails utterly to sabotage Delilah's wedding. Burt hoped to make up for his pauper wedding by renewing his vows here, but comes up with a budget comfortable alternative.
Virginia, Burt, Jimmy, Sabrina, Maw Maw and Hope camp out on the front lawn after their house becomes tented for termites, but getting caught in the rain is the least of their problems. After learning that Hope hit a boy at day care, the family attempts to stop arguing out of fear that she will follow in her serial killer mom's footsteps.
Supermarket manager Barney's wicked ex Gloria is in town and gets him to employ her cute teenage son, Trevor. Jimmy's sympathy for the kid turns into panic when Sabrina clearly prefers his wittier humor and boyish charms and Trevor digs her. So Jimmy lets himself be blackmailed into any crazy effort to find Trevor alternative dates. Meanwhile Burt overcomes Virginia's initial disgust to retrieving Maw Maw's loose golden tooth from the toilet, which proves an eventful effort.
Jimmy, Virginia, Burt, Sabrina, Maw Maw and Hope borrow a house to impress Burt's wealthy parents who have decided at the last minute to celebrate Thanksgiving with the family. Things get interesting when the real homeowners return early, and Burt's folks get a taste of what life is really like for Burt and Virginia.
The Chances dream of winning riches and fame at the National Invention Convention Extravaganza, whose star Andrew Dice Clay is announced to a stop in town. Each family member is supposed to come up with one brilliant novelty, but only greediest Virginia actually does so alone, sponges under the armpits to save deodorant. Jimmy dares not offend Sabrina by turning down her 'improvement', which actually wrecks his idea, a mob operated by a crawling baby. Burt and half-wit neighbor protégé Andrew come up with bro-gurt, macho flavors of yogurt. Competition day proves ...
Jimmy's close relationship with daughter Hope has him sewing dresses, baking cookies, and wearing fancy hats at tea parties until Burt yells at him to "Stop being a girl!". In an attempt to be a little more 'dangerous' he decides to spend some time with Frank. Strangely enough waking up in Franks house after a night of partying lets Jimmy discover a new side to Frank, one that he really wants to bond with to the rest of the families horror. Discovering they were bullied by the same guy back in school, Jimmy and Frank set off on a quest for revenge that has some pretty...
A remarkably recognizable movie forces the Chances to have a look at their own family life. For Jimmy, Maw-Maw's spirit takes him on a frightening journey to an alternative future, if he hadn't met Hope's mother and hence remained childless. the consequences prove surprisingly grave for just about every relative and even his supermarket colleagues.