Gabriel tells Dean he is "blowing Jonestown" a reference to the notorious mass suicide led by the leader of the cult, Jim Jones. There were 909 killed with all but two deaths caused by cyanide poisoning. On tapes recorded prior to the event Jones and other members referred to this suicide as "revolutionary suicide". In Hammer of the Gods the location is in Indiana, and Indianapolis Indiana is where The Peoples Temple cult was formed. In 1977 members of The Temple moved to Guyana where Jonestown was erected in an effort to escape the building pressure and allegations from various sources. Many of the members of The Peoples Temple believed that the promise from Jones that Guyana would be a utopia, or paradise. This corresponds with what is happening between the angels, devil, and the gods.
While addressing the gods, Dean says: "Alright you primitive screwheads, listen up!" This is a direct quote from the 1992 Sam Raimi film Army of Darkness, the third installment of the Evil Dead series.
Jokes are the mainstay of the set, Jared and Jensen glued Denny Erickson to his chair, in turn Denny used Liquid Nails on the doors of Jared's Trailer, while Jensen watched lookout. Apparently as a stunt coordinator Denny was a little too serious in the rehearsals and Jared kept saying: "Why can't you be more chill, you know stick around with us, relax", and then came the jokes ...
Pestilence is played by Matt Frewer who also starred in the 1994 mini series adaptation of the Stephen King novel The Stand, in which a battle between heaven and hell takes place after most of the earth's population has been wiped out by an extremely aggressive flu.