Writer and Director Sarah Polley chose to use the song "Video Killed the Radio Star" in key scenes, because it was her brother's favorite song.
In 2009, the script was listed in The Black List. The Black List is an annual publication that names the best unproduced screenplays of the year it is published.
Michelle Williams said in an interview that she, Sarah Silverman, and Jennifer Podemski didn't want to film the full nude shower scene. But they agreed to because it fit the story. She said it, like other nude scenes she's filmed, is like sky diving. The first few moments are terrifying when you strip off your robe in front of the crew, and then you get used to it and it may even be fun. But she said it was much easier doing that shower scene than the nude scenes she did in previous films with men. She said it's much easier to be naked with other girls than boys.
Sarah Silverman said in an interview that she loved working with Seth Rogen because "he is the least neurotic Jew I've ever met in my life. I don't know that it has to do with being a Canadian or that his parents are married and in love and have room to love their kids or what, but he's so undaunted by things. He's like, 'Hmm, this is a line. I'll say it like it's real.' It's simple for him."