Galactus is about to devour Earth and not even the combined power of all the Super Heroes (and even some villains) can stop him. Iron Man decides to gather all the Infinity Fractals and reforge the Infinity Sword.
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Title card's issue homage: Fantastic Four #243. See more
In the previous episode (The Super Hero Squad Show: Last Exit Before Doomsday!
), which is Part 1 of this story, Dr. Doom crashed through the giant eye in his headquarters, leaving a giant hole. The hole is gone in this episode, even though it takes place at the same time - and with Dr. Doom packing to evacuate Earth, he wouldn't have bothered to get it fixed right away. Of course, the Super Hero Squad go and make a new hole in the eye in this episode, though even that hole is fixed when Galactus drops the fumigation bombs later on. See more
Once upon a previous episode, Galactus was destroying the Earth.