Idealistic young Dr. Lily Brenner, along with fellow doctors Mina Minard and Tommy Fuller, arrive in "la ciudad de las estrellas" (the city of stars), a tiny town in the South American jungle which has one understaffed, under-stocked medical clinic. All of these young doctors are running away from personal demons, but they aren't the only ones with emotional baggage. They're introduced to the legendary and enigmatic Ben Keeton, who was the youngest Chief of Surgery at UCLA but who walked away from it all to found the clinic. Together with his right-hand doctor, Otis ...
When a 12-foot anaconda snake takes hold of a wildlife photographer, Zee, Lily and Ben spring into action. Meanwhile Tommy learns a tough cultural lesson and Mina struggles to get along with new colleague Ryan.
When a robbery deprives the clinic of all of their meds, the docs must scramble to keep treating patients. Tommy must save a frat brother whose hang-over turns out to be something much worse. Ryan must deal with a schoolgirl who's been bitten by an insect and gotten a serious problem that strikes too close to home. Meanwhile Otis must revisit his own demons in order to obtain some much needed pain relief for a man with burst appendix.
After the medevac helicopter crashes in the jungle, the team must jump into action to save the lives of their patients and the pilots, while Ryan searches for a missing girl and Lily learns a shocking secret that Mateo's been keeping.
A paragliding accident leaves a vacationing couple in peril, while Mina is forced to take control of Ryan's care, and Charlie is reunited with his absent mother who is in need of help from the clinic and from Tommy.
The country's Holy Week festivities take a chaotic turn when a truck float crashes, and Ben makes a difficult call as Ryan's health deteriorates. Meanwhile, Lily forces her own issues aside when tragedy strikes Mateo's family farm.