Since Victoria's husband's disappearance, the women have been monitored closely by an FBI agent (Thomas Lennon). Melanie tells Alec (Jay Harrington) that she's pregnant and Joy discovers she's now irresistible to men.
Joy's baby daddy, Simon (Craig Ferguson), meets his son and grandson for the very first time as they pretend to be a happy family to get Wilbur into a prestigious pre-school. Melanie and Elka try to find the perfect doctor.
Victoria wants to be nominated for an Oscar and gets her friends to convince Academy members to nominate her. Melanie's assigned a teen idol (Jason Priestly); Joy's given an indie darling (Sarah Hyland). Elka reunites with Roy.
When the women try to adopt a puppy, the Rescue Center's volunteer, Doug (Max Greenfield), determines if they are dog-worthy. Elka's relationships with Mamie (Georgia Engel) and Roy (John Mahoney) take an interesting turn.
Melanie uses her illness to get tickets to country star Chase Jackson's (Chris Isaak) sold-out concert, while her friends also cash in on her "tumor perks." Vicotoria's new online suitor may not be the man he says he is.
The ladies fly to NYC. Victoria wants to come clean to Maddie Banks for not telling her about an audition call back for 'Sofia's Choice' when they were roommates years earlier; Melanie, Joy and Elka cross things off their bucket lists.
The women fly to Los Angeles to watch Victoria announce the Oscar nominations. Elka gets campaign advice from a statistics expert, Victoria has nerves over the unknown, and Joy meets the man she's going to marry.
During a major storm the ladies are stuck in the house with some unwanted guest; Elka thinks a ghost of a woman murdered 50 years ago has returned to seek revenge; Joy's Mother visits with her new boyfriend someone for her past.
Melanie rekindles a relationship with Donald and discovers he's coaching Elka's political opponent for the debate. Things heat up between Victoria and J.J. but he has the jitters because the only women he has slept with was his late wife.