A security guard in a weed store, stops a robbery. The guard is shot and wounded as he kills one of the thieves. The police have lots of questions that go unanswered. Rizzoli & Isles search for the dead robbers accomplice. Later Rizzoli continues her efforts to protect Isles and Angela.
When a gun battle rages in a quiet neighborhood, leaving one dead, Jane and Maura are thrown into the secretive world of an Eastern European gang. Maura comes down with a fever while juggling work and play, and Angela and Kent prescribe several home remedies that have a surprising effect.
When a state trooper is killed in Maine, the getaway car is traced back to the mastermind of the attacks on Jane. The team must now unravel the mystery of the mastermind's obsession with Jane in order to keep her safe, and turn the hunter into the hunted.
In the season premiere, in the aftermath of the shooting at the end of season six, the team must use every tool at their disposal to find the elusive Alice Sands and bring her to justice, before Jane's life is destroyed.
When a mailman is killed, the team must work with a brash, eccentric postal inspector, who believes the mailman's murder is part of a larger conspiracy. Maura continues to struggle with the ramifications of her injury, and Angela intervenes when she discovers Korsak has gotten Kiki (recurring guest star CHRISTINA CHANG) a terrible birthday present.
In the 100th episode of the series, Jane risks her safety to go undercover in a county jail in an effort to acquire details from a woman believed to be in some way involved in a brutal double-homicide.
A dead man is found handcuffed to a bed in his own home; as Korsak's retirement party approaches, everyone makes a video to say goodbye; the group says farewell and plans for their next adventure. Series Finale.