After the check-up with Oyoji, Courtesan Nokaze asks Jin to see another patient. He discovers a former courtesan in the last stages of syphilis. There is no cure, since penicillin has not yet been discovered. Jon tries to persuade the rest of the prostitutes at the brothel to accept to an examination for signs of syphilis. However, they call him a pervert and refuse. Feeling defeated for his inability to help Courtesan Nokaze, Jin suddenly recalls the first meeting with Miki. She presented him with the procedure to create penicillin. He immediately seeks the help of the staff at the Western Medicine Office and creates a penicillin factory. Even with the inconsistent results of the process, he creates an effective dose to administer to the former courtesan. Her physical appearance is healed, yet she was too far along in the illness to be saved. It continues to be a slow process to create and administer the cure to the rest of the prostitutes at Yoshiwara. Even with the discovery of penicillin, Jin still feels defeated that he could not save the one person Courtesan Nokaze asked him to. Saki surprisingly asks him if someone in the future discovered penicillin. He shares his photo with her and relays the story of how Miki educated him on creating penicillin. With Jin making so much medical history, there is uneasiness in the hierarchy of the Western Medicine Offices.
—ley-moon