In the episode, guest star James Frain's character is scared of the number 5 hinting at the actors famous movie "Where the Heart Is". In the movie, co-star and love interest Natalie Portman is also terrified of the number 5 because horrible things always seem to happen when the number is involved. See more
Dr. Meredith Grey
We're all susceptible to it. The dread and anxiety of not knowing what's coming. It's pointless in the end. Because all the worrying, and all the making of plans for the things that could happen it only makes things worse. So, walk your dog, or take a nap. Just, whatever you do, stop worrying. Because the only cure for paranoia is to be here. Just the way you are.