Just as Selene sees Lane wheeling her daughter into the elevator, she comes upon Michael's body in a cryotank. She shoots a hole in the tank to release him and then goes after Eve. Sebastian sees Lane loading Eve into a van and tries (unsuccessfully) to stop him. Selene shows up in time to flip the van and kill the Lycans riding inside. Sebastian shoots at Lane, hitting him several times before Lane turns on him. Suddenly, Eve exits the van and goes after Lane, who has morphed into his Lycan form. As Eve fights Lane, David shows up to help. Eve eventually rips out Lane's throat. Meanwhile, Quint has morphed into his superlycan form and comes after Selene, batting her around like a rag doll and throwing cars at her. Forced to morph back into his human form in order to fit through a small opening, Quint corners Selene. In a last ditch effort, Selene rips open his abdomen with her hand. When she removes it, however, the wound closes immediately. "I heal instantly," Quint mocks, "I'm counting on it," Selene replies and tosses him the ring from the grenade she has just planted inside him. A few seconds later, Quint explodes. As sirens begin approaching, Sebastian tells Selene, Eve, and David to get away while he stays behind to buy them some time. The three of them return to Michael's cryotank to find it empty. In a vision, Eve sees Michael on the roof. In the final scene, they run up to the roof, but Michael is gone. While holding Eve's hand, Selene says in a voiceover:
Though the world has changed, our enemy remains the same. The Lycans will rebuild and will hunt for her father as they did for her. But as they grow stronger, so will we. The vampire coven will not only survive this world, we will reclaim it.