Jorma Taccone, the films director, plays a drinking game on the DVDs commentary track where he takes a drink of beer every time MacGruber's name or any variation of it is used in a line of dialogue. He drank four beers.
Lee David Zlotoff, creator of the TV series MacGyver (1985), felt that his legal right to make a film version of his series was compromised with the release of MacGruber (2010). His lawyer sent several cease-and-desist letters to the production company and met with litigators although ultimately, no legal action was taken.
In the original SNL sketches, no on-screen explanation was provided for Kristen Wiig replacing Maya Rudolph as MacGruber's partner (the off-screen reason being Rudolph's departure from the show). The film addresses the switch by explaining that Rudolph's character died.