Nurse 's first day at MercY hospital starts grimly when she's ordered to . Veteran Veronica is a haughty pest, practically bullying everyone, even doctors, regardless of consequences for the hospital. Her husband Mike is used to the same, yet proposes again.
Faced with pressure from Mike to start a family, Veronica has to decide whether her affair with Dr. Sands really is all in the past. And, as she fights to get treatment for a fellow veteran, Veronica's own unresolved issues from Iraq are brought to light. Sonia experiences the perks and drawbacks of dating a cop and winds up as the unwitting marriage counselor for two feuding patients with a quirky love-hate relationship. Meanwhile, Chloe tries to give hope to a cynical young patient and contemplates taking her crush on Dr. Sands to the next level.
After announcing to her family that she's trying to get pregnant, Veronica finds herself uniquely determined to save a pregnant woman and her unborn child in the aftermath of a horrible car wreck. Meanwhile, Dr. Harris, fed up with Veronica's repeated affronts to his authority, calls for a disciplinary hearing to determine Veronica's future at Mercy Hospital. Sonia helps a sleepwalking patient in his struggle for independence and cautiously moves forward in her relationship with Valentino, while Chloe goes on an ambulance ride-along and makes a discovery that will ...
As her secret affair with Dr. Sands rapidly becomes less and less secret, Veronica takes a cue from a courageous cancer patient and contemplates facing her fear by coming clean to her husband Mike. Sonia gets relationship advice from an experienced patient and begins to question her arm's-length approach to dating, just as her cop-boyfriend Valentino goes missing. Meanwhile, Chloe plans a reunion with a former boyfriend but her evening takes an unexpected turn when she learns some surprising news.
Veronica is shocked to learn she might be pregnant, but worries that not even a baby can save her marriage to Mike. Determined to regain some control in her life, she teams up with a grief-stricken Dr. Harris to wage a full-fledged war against death at Mercy Hospital. Meanwhile, Sonia helps a teenage beauty queen accept a life-changing diagnosis, Chloe uncovers the nasty secret her fireman-boyfriend has been keeping from her and Dr. Sands gets closer to Dr. Jelani while helping to organize a "Bike to Work Friday."
Veronica helps a patient cope after a terrifying experience on the operating table launches him into a crisis of faith. Meanwhile, she suspects that Mike has moved on and started dating again. Sonia tries to track down the next of kin for a young patient after a car accident, but instead uncovers a terrible secret that will change the girl's life forever. And Chloe mediates a bitter family feud when her patient's children can't agree on a course of treatment for their dying father.
Veronica has her hands full when a trio of promiscuous college students is admitted with meningitis and their soapy love triangle has the entire Mercy staff drawing comparisons to Veronica's own complicated love life. Meanwhile, Chloe helps with wedding plans when a bride-to-be comes in with the flu and receives a much more serious diagnosis. Sonia manages a defiant hand transplant patient who wants his donor hand amputated after discovering it once belonged to a pedophile and Dr. Sands gets a surprise visit from his freewheeling sister.
Thrilled to be back together with Sands, Veronica gets ready for their first official date - until a shocking encounter with a stranger turns everything upside down. Meanwhile, Chloe is put to the test in the fast-paced, high-stakes world of the ER after she and Angel get re-assigned by the arrogant new head of the ICU, Dr. Joe Briggs And as Sonia bonds with the rich son of her elderly patient, she begins to question the modest lifestyle she's settled into with Valentino.
Veronica begins the difficult process of confronting her PTSD with her therapist. Although Sands is eager to move forward with their relationship, Veronica finds herself siding with Briggs against him in a dispute over a patient's treatment. Chloe and Harris team up to help a cute college football player with a potential brain injury and Angel butts heads with an eccentric ER patient. Meanwhile, Sonia cares for two hipsters after their hair-brained attempt to win a girl's heart lands them in the hospital, but their romantic gesture inspires her to make her own.
Following a prison riot, several injured prisoners are brought to Mercy for treatment. Veronica finds herself sympathizing with her patient, but she's shocked to discover a dangerous secret he's been keeping. Chloe tries to convince her college football player boyfriend to take time off from practice to treat his head injury before it's too late. And, when Sonia's seemingly tough patient admits he's terrified to return to prison, she can't help but worry that she may be headed there too - unless she comes clean about her involvement in her former patient's suicide. ...
When a friend from their Iraq days shows up unexpectedly, Veronica and Sands are suddenly faced with a life-altering decision. Sonia, increasingly intimidated by a stalker's threats, gets help from a surprising source, while Chloe worries that her boyfriend is causing irreparable brain trauma by playing football against medical advice. And, after Angel's friend is brutally beaten, Briggs worries that his mafia connections may have played a role. Meanwhile, a former flame comes back into his life, with dangerous consequences.
When two boys get trapped in an abandoned building, Veronica finds herself in the right place at the right time to help them. Back at the hospital, Chloe pressures doctors to perform a risky surgery to save her comatose boyfriend from brain death, and Sonia treats a psychic patient who makes a mysterious prediction about her future. Meanwhile, Briggs tries frantically to raise the funds needed to pay off his high-stakes debt with the mafia before it's too late, and Sands considers a job offer to return to Afghanistan with a medical relief effort.