An unknown aggrieved man shoots new bride to be Kim Mullins. Her new husband Sam agrees to organ donation when she is declared brain dead but her mother Nancy is against it and gets a court order to stop Sam. Miranda goes out of her way to find lungs for her patient Mark Wilson and goes to South Carolina in the hope of harvesting Kim's organs and college basketball player Anton Weathers needs a new heart and hopes to benefit from Kim also but is devastated when he finds he will not be able to go pro after his transplant.
Dr. Jordon, Miranda, David, Andy and the others deal with the captain of a firehouse who needs a lung transplant. One of his firefighters must make the tough decision of whether or not she wants to be a living donor. Meanwhile, Andy faces a personal and professional dilemma when his uncle comes to Three Rivers for treatment from a stab wound, but requests that Andy keep it to himself.
Andy's nemesis, arrogant heart surgeon Dr. Luc Bovell, returns to Three Rivers after a long absence and with pioneering robotics that could change the face of surgery at Three Rivers. Meanwhile, David's long-dormant Korean is tested when a Korean female air-passenger is admitted and he has to act as translator.
Andy puts his patient Kuol at the top of the donor list to receive a new heart after his condition takes a turn for the worse. However, his transplant is put in jeopardy when the cops threaten to seize the money that was raised for Kuo's surgery.