At the Three Rivers Hospital in Pittsburgh, a clinic specializing in organ transplants, Dr. Andy Yablonski is the highly-skilled workaholic lead organ transplant surgeon, whose good-natured personality and sarcastic wit makes him popular with both his patients and colleagues. His co-workers include Dr. Miranda Foster, a surgical specialist with a rebellious streak and fiery temper who strives to live up to her deceased father's excellent surgical reputation; Dr. David Lee, a womanizing surgical resident who's broken as many hearts as he's replaced; Ryan Abbott, the ...
Andy, Lisa and the rest of the team work to save an 18-year-old college student in need of a double lung transplant, only to find that she cannot be placed on the list. Andy looks for alternatives to save her life. Meanwhile, Dr. Jordan has a patient in need of new kidneys and issues arise with the donor. Also, Andy and Miranda treat a former patient, who needs a new heart as well as a second chance with mending fences with his estranged son.
Andy goes out on a limb for a patient, who is a former drug user in convincing the UNOS (United Network for Organ Sharing) to allow the transplant, which takes a turn for the worse when the patient disappears from the hospital before the surgery. Meanwhile, Dr. Jordan treats a very dedicated lawyer who ends up threatening to sue her. Also, David and Ryan encounter a unique situation when they head to pick the donation.
Following a bus crash, the parents of a high school football player must make a heartbreaking decision whether to donate his organs to save the lives of his fellow teammates. Meanwhile, Andy and Ryan race against the clock to find a procurement team to give a boy a heart transplant he desperately needs.
Andy's police detective wife Rena, arrives at Three Rivers when her partner, Detective Phillip Lombardi, suffers a heart attack, where its soon revealed that Lombardi needs a new heart due to an aortic aneurysm. Andy ends up risking everything by trying a new procedure to save him. Meanwhile, an old patient returns to Three Rivers with a secret about Dr. Jordan.
Lisa responds to an accident at a local fair in which an eight-year-old boy is seriously injured and this bring up some painful memories. Meanwhile, Andy and David continue to work on getting a VAD for Kuol before it is too late. Also, Miranda and Dr. Jordan treat a young girl who collapsed during a gymnastic event and must deal with a personal issue.
Andy treats Victor, a car crash patient who's dying from ALS (amyotrophic lateral sclerosis) who wants to die from his injuries so his organs can be used to save others at Three Rivers. Meanwhile, David deals with the parent of three young foster children, suffering from pulmonary hypertension, who refuses to be admitted into the hospital. Miranda deals with a former heart recipient, named Barbara, who's new heart begins to cause complications, while Ryan is stuck with planning a donors-recipients reception at the hospital.
Tracy Allen is the wife of a San Francisco billionaire who arrives at Three Rivers in need of a new liver. But complications set in when David and Pam travel to Youngstown, Ohio to pick up one from the donor, a murder victim of highwaymen, a setback occurs when the liver is cancer ridden. As a result, Tracy's husband, John, defies Dr. Jordan's advice and resorts to buying a new liver for her on the black market. Meanwhile, a friend from Andy's criminal past, named Michael, resurfaces who anonymously gives a hearty donation to the hospital for Kuol's heart transplant ...
An unknown aggrieved man shoots new bride to be Kim Mullins. Her new husband Sam agrees to organ donation when she is declared brain dead but her mother Nancy is against it and gets a court order to stop Sam. Miranda goes out of her way to find lungs for her patient Mark Wilson and goes to South Carolina in the hope of harvesting Kim's organs and college basketball player Anton Weathers needs a new heart and hopes to benefit from Kim also but is devastated when he finds he will not be able to go pro after his transplant.
Andy must decide if he will allow a woman to start a "daisy chain" and donate her kidney to another patient on the chain until an exact match is found for her husband. Meanwhile, Andy suspects that a recent patient is rejecting his new heart.
Dr. Jordon, Miranda, David, Andy and the others deal with the captain of a firehouse who needs a lung transplant. One of his firefighters must make the tough decision of whether or not she wants to be a living donor. Meanwhile, Andy faces a personal and professional dilemma when his uncle comes to Three Rivers for treatment from a stab wound, but requests that Andy keep it to himself.
Andy's nemesis, arrogant heart surgeon Dr. Luc Bovell, returns to Three Rivers after a long absence and with pioneering robotics that could change the face of surgery at Three Rivers. Meanwhile, David's long-dormant Korean is tested when a Korean female air-passenger is admitted and he has to act as translator.
Andy puts his patient Kuol at the top of the donor list to receive a new heart after his condition takes a turn for the worse. However, his transplant is put in jeopardy when the cops threaten to seize the money that was raised for Kuo's surgery.