The whole episode is basically a giant homage to Beast Wars: Transformers (1996). For one, it was written by Lawrence G. DiTillio and Bob Forward, who were also the writers of the aforementioned series. The title of the episode is a reference to the Predacons from that show.
The animals Blackarachnia encounters are clear homages to the main cast of Beast Wars: Transformers (1996). The rhino represents Rhinox, the gorilla Optimus Primal, the giant rat Rattrap, and the cheetah Cheetor.
This is the first time we get to see what Blackarachnia's head looks like under her helmet, and also the first time Waspinator has appeared after the final episode of Beast Machines: Transformers (1999).
Several characters from Beast Wars: Transformers (1996) have been updated and included in the series. These include Blackarachnia, Waspinator and Rattrap (named as Rattletrap). As well as this, animals that resemble the alt forms of the core Maximals are seen at the end of Predacons Rising (itself referencing the opposing faction from the series), furthermore characters from the series' sequel, Beast Machines have also been seen. These include Strika and Derrick Wyatt (the lead character designer) even posted a design for Botanica on his blog.
On another note, much of the creative team from Beast Wars also worked on this series.
Waspinator, after being blown apart and pulling himself together mumbles "Waspinator cannot go offline. Waspinator have plans." This is a reference to the original Waspinator, who also got dismantled in almost every episode, yet survived each time. The line "Waspinator has plans" is also one of the more memorable lines his original version said in Beast Wars: Transformers (1996).